Who can administer
May be administered by registered competent doctor or nurse/midwife
Important information
- Restricted to micro/ID advice only (Red-light antimicrobial)
- If documented immediate, or severe delayed hypersensitivity reaction to penicillin: DO NOT GIVE THIS DRUG
- See under Dose for adjustments required in Renal impairment
Available preparations
Zinforo 600mg vial
Reconstitution
Water for injection
20ml per 600mg vial
Dilute further prior to administration
Infusion fluids
Sodium chloride 0.9% or Glucose 5%
Methods of intravenous administration
Intermittent intravenous infusion
- Add required dose to 100 to 250mL infusion fluid - choice of volume depends on clinical status of patient
- The total time between starting reconstitution of the drug and completing preparation of the intravenous infusion should not exceed 30 minutes
- Administer over 5 to 60 minutes (for twelve-hourly doses), or 120 minutes (for eight-hourly doses)
- Infusion related reactions can be managed by prolonging infusion duration
- A 50ml infusion may be used if required (eg fluid restriction) but the residual volume in the infusion line must be flushed through at the same rate to avoid significant underdosing
Dose in adults
Standard dose
- Give 600mg every twelve hours
High dose
- Give 600mg every eight hours
Renal impairment
| Renal impairment |
Standard dose |
High dose |
| eGFR 31 to 50 ml/minute |
400 mg every 12 hours |
400 mg every 8 hours |
| eGFR 15 to 30 ml/minute |
300 mg every 12 hours |
300 mg every 8 hours |
| End stage renal disease, including haemodialysis |
200mg every 12 hours |
200mg every 8 hours |
Hepatic impairment
- No dosage adjustment required
Storage
Store below 250C
References
SPC January 2021
Therapeutic classification
Cephalosporin antibiotic (5th generation)
