Prochlorperazine Intravenous for Adults

Who can administer

May be administered by registered competent doctor or nurse/midwife

Important information

• Unlicensed use
• Reserved for use in the Emergency Dept in the management of acute migraine
• Doses in this monograph are expressed as the salt. (The doses have been rounded to closest reasonable dose that can be administered)
  • Many references quote doses as base.  Take care when interpreting reference sources
• Patient must lie down during and for 30 minutes after administration to reduce the risk of hypotension ^{(ref 1)}

Available preparations

Stemetil (Prochloperazine Mesilate) 12.5mg per ml ampoule

Reconstitution

Already in solution
Draw up using a 5 micron filter needle

Infusion fluids

Not applicable - product ready for use

Methods of intravenous administration

Slow intravenous injection

• Give slowly at a maximum rate of 6.25mg /minute ^{(ref 1)}
• Dilute 1ml to 5ml with Sodium chloride 0.9% to aid slow administration ^{(ref 1)}

Dose in adults

• Typical dose: 6.25 to 12.5mg ^{(ref 2)}
• Do not give more than 12.5mg as a single dose ^{(ref 1)}

Monitoring

Blood pressure and heart rate for at least 30 minutes post injection  ^{(ref 1)}

Further information

• Ensure suitable antidote, e.g. benztropine or procyclidine ^{(if available)}, readily available in the event of a dystonic reaction 

Storage

Store below 25⁰C

References

1. Injectable Medicines guide, Accessed via Medusa 24/02/2026

2. Martindale, accessed online 25th Feb 2026 (doses as base: specified as salt on this monograph- rounded to closest reasonable dose that can be administered)

Therapeutic classification

Drug used in nausea and vertigo