Who can administer
May be administered by registered competent doctor or nurse/midwife
Available preparations
Dynastat 40mg vial
Reconstitution
Sodium chloride 0.9% or Glucose 5% - add 2ml per 40mg vial
Dissolve the powder using a gentle swirling motion
Methods of intravenous administration
Bolus intravenous injection
- Administer over 1 to 2 minutes (ref 1)
Dose in adults
Usual dose
- Give 40mg stat, followed by 20 to 40mg every six to twelve hours as required
- Maximum dose 80mg daily
- Elderly patients weighing less than 50kg - use half initial dose, maximum daily dose 40mg
- Use for the shortest duration possible, at the lowest effective dose
- There is limited clinical experience with treatment beyond three days
Renal impairment
- Severe renal impairment (CrCl <30ml/minute), or patients predisposed to fluid retention: Start with 20mg and monitor renal function closely
Hepatic impairment
- Severe impairment (Child Pugh 10 or more) Contraindicated
- Moderate impairment (Child Pugh 7 to 9): Use half the recommended dose (maximum daily dose 40mg)
- Mild impairment (Child Pugh 5 - 6): No dosage adjustment necessary
Storage
Store at room temperature
References
SPC via EMEA (downloaded 19th Jan 2023) 24/01/2012
Therapeutic classification
Anti-inflammatory agent (COX-2 inhibitor)
